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Skipping doses can increase your risk of infection that is resistant to medication Levofloxacin 250mg Tablet Sandoz Inc. Pneumonia or Pseudomonas infections. You may take levofloxacin tablets with meals or on an empty stomach. Intravenous dosage Adults 750 mg IV every 24 hours for 5 days or 250 mg IV every 24 hours for 10 days. 500mg x1, then 250mg IV/PO Q48h. The usual dose is 500 mg daily, although for some types of infection a dose of 250 mg daily is sufficient, and for others, 500 mg twice daily is needed. LEVAQUIN prescription and dosage sizes information for physicians and healthcare professionals. 750mg x1, then 500mg IV/PO Q48h Levofloxacin (Levaquin) 250mg and 500mg tablets are listed on the Ontario Drug Benefit Formulary as Limited Use benefits. This medicine is best taken with a full glass (8 ounces) of water. Dose as in GFR 10 mL/min; HDF/high flux :Not dialysed.. 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